Shaker, S., Osman, B., Salama, S., Khalaf, M., Kamel, M. (2025). The Effect of Sodium Benzoate on the Pathway of Autophagy in the Cardiac Tissues of Rats. Journal of the Medical Research Institute, 46(1), 47-60. doi: 10.21608/jmalexu.2025.366736.1053
Sara A Shaker; Basma Osman; Susan Mohamed Salama; Mokhtar Khalaf; Maher A Kamel. "The Effect of Sodium Benzoate on the Pathway of Autophagy in the Cardiac Tissues of Rats". Journal of the Medical Research Institute, 46, 1, 2025, 47-60. doi: 10.21608/jmalexu.2025.366736.1053
Shaker, S., Osman, B., Salama, S., Khalaf, M., Kamel, M. (2025). 'The Effect of Sodium Benzoate on the Pathway of Autophagy in the Cardiac Tissues of Rats', Journal of the Medical Research Institute, 46(1), pp. 47-60. doi: 10.21608/jmalexu.2025.366736.1053
Shaker, S., Osman, B., Salama, S., Khalaf, M., Kamel, M. The Effect of Sodium Benzoate on the Pathway of Autophagy in the Cardiac Tissues of Rats. Journal of the Medical Research Institute, 2025; 46(1): 47-60. doi: 10.21608/jmalexu.2025.366736.1053
The Effect of Sodium Benzoate on the Pathway of Autophagy in the Cardiac Tissues of Rats
1Biochemistry department, medical research institute, Alexandria University
2Department of Biochemistry, Medical Research Institute
3Biochemistry department, Medical Research Institute, Alexandria university
4Department of Environmental Studies, Institute of Graduate Studies and Research, University of Alexandria,
5Department of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt
Abstract
Sodium benzoate (SB) is a crucial food preservative utilized in a variety of food products as well as in other industries. The description of SB as a safe additive is true, but because it is frequently found in foods and drinks, the total dose consumed by human cannot be fully counted and controlled. As a result, many people may be exposed to high doses of SB every day without being aware of it. The present study aimed to investigate any potential dose-dependent adverse cardiac effects of SB in male rats and to evaluate the possible link between exposure to SB and the change in the activity of cardiac autophagy. The study was conducted on 40 male albino rats that were classified into two main groups; control group and SB groups treated with various doses (1,10 , 50 , 100 , 250 , 500 , and 1000 mg/Kg BW/day) orally every day for 90 days. The results showed that SB has a dose-dependent deteriorative effect on the cardiovascular system at doses of 50 mg/Kg BW/day and higher. These effects were through interrelated mechanisms including redox imbalance, enhanced oxidative stress, pro-inflammatory and concurrent stimulation of autophagic and apoptotic cell deaths in cardiac tissues. Conclusion: The results of present study indicated that the dose of SB below 50 mg/Kg BW/day can be considered a safe dose with the least possible side effects on cardiac functions and autophagy in cardiac tissues, and the effect of this dose on other body organs deserves further researches.
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