Saleh, S., Sharshera, H., Sadek, N., El Maghraby, S., Kandil, N. (2024). Plasma level of soluble glycoprotein IIb/IIIa in Beta-thalassemia major patients in relation to thrombotic risk score. Journal of the Medical Research Institute, 45(4), 1-6. doi: 10.21608/jmalexu.2024.335991.1031
Sally A.M Saleh; Homam Mohamed Sharshera; Nadia Aly Sadek; Shereen Mohamed El Maghraby; Noha Said Kandil. "Plasma level of soluble glycoprotein IIb/IIIa in Beta-thalassemia major patients in relation to thrombotic risk score". Journal of the Medical Research Institute, 45, 4, 2024, 1-6. doi: 10.21608/jmalexu.2024.335991.1031
Saleh, S., Sharshera, H., Sadek, N., El Maghraby, S., Kandil, N. (2024). 'Plasma level of soluble glycoprotein IIb/IIIa in Beta-thalassemia major patients in relation to thrombotic risk score', Journal of the Medical Research Institute, 45(4), pp. 1-6. doi: 10.21608/jmalexu.2024.335991.1031
Saleh, S., Sharshera, H., Sadek, N., El Maghraby, S., Kandil, N. Plasma level of soluble glycoprotein IIb/IIIa in Beta-thalassemia major patients in relation to thrombotic risk score. Journal of the Medical Research Institute, 2024; 45(4): 1-6. doi: 10.21608/jmalexu.2024.335991.1031
Plasma level of soluble glycoprotein IIb/IIIa in Beta-thalassemia major patients in relation to thrombotic risk score
2Professor of Hematology, Medical Research Institute, Alexandria University, Egypt
3Assistant professor of Hematology, Medical Research Institute, Alexandria University, Egypt
Abstract
Background: Multifactorial mechanisms are tangled in the pathogenesis of Thromboembolic events (TEE) in thalassemia major( TM) including the combination of the components of the hemostatic process together with the disease-specific features. GpIIb/IIIa is an integrin complex found on surface of platelets. It is a receptor for fibrinogen and prothrombin. Its activation leads to platelet aggregation. Aim: Estimate the plasma level of s GpIIb/IIIa in β- TM Subjects and methods: The study was conducted on 67 individuals divided into 2groups. The first group included 47 TM patients, while the second group included 20 healthy control subjects. complete physical examination , CBC, serum ferritin, CRP, and s GpIIb/IIIa by ELISA were done. Results The serum level of GpIIb/IIIa was significantly higher in the TM group with a p value Conclusion: TM are characterized by stronger platelet aggregation as reflected by increased GpIIb/IIIa which was associated with high , and intermediate TRT-RSS .
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