(2016). STUDY THE ROLE OF VITAMIN D IN THE PATHOPHYSIOLOGY OF SEVERE ASTHMA. Journal of the Medical Research Institute, 37(1), 24-32. doi: 10.21608/jmalexu.2016.112122
. "STUDY THE ROLE OF VITAMIN D IN THE PATHOPHYSIOLOGY OF SEVERE ASTHMA". Journal of the Medical Research Institute, 37, 1, 2016, 24-32. doi: 10.21608/jmalexu.2016.112122
(2016). 'STUDY THE ROLE OF VITAMIN D IN THE PATHOPHYSIOLOGY OF SEVERE ASTHMA', Journal of the Medical Research Institute, 37(1), pp. 24-32. doi: 10.21608/jmalexu.2016.112122
STUDY THE ROLE OF VITAMIN D IN THE PATHOPHYSIOLOGY OF SEVERE ASTHMA. Journal of the Medical Research Institute, 2016; 37(1): 24-32. doi: 10.21608/jmalexu.2016.112122
STUDY THE ROLE OF VITAMIN D IN THE PATHOPHYSIOLOGY OF SEVERE ASTHMA
Background: Vitamin D deficiency has been suggested to play a role in the pathophysiology of asthma. Several suggested mechanisms have been proposed including airway remodelling. The aim of our study was to investigate the role of vitamin D serum level in the pathophysiology of airway remodelling in severe refractory asthma. Subjects and methods: The present study was conducted on 20 severe, 10 non-severe asthma patients and 15 control subjects. Pulmonary function tests, sputum matrix metalloproteinase-9 (MMP-9) and serum vitamin D3 were measured in all subjects. Patients with airway obstruction (Forced expiratory volume in one second (FEV1) <80%) performed bronchodilator reversibility testing. Results:Vitamin D deficiency was prevalent among all our asthma patients. Although there was no significant difference in serum vitamin D levels between severe and non-severe asthmatic patients, serum vitamin D levels were positively correlated with the degree of current clinical control, as measured by Asthma Control Test (ACT). Serum vitamin D levels were negatively correlated with sputum MMP-9 levels in our asthma patients. The degree of bronchodilator reversibility was positively correlated with serum vitamin D and negatively correlated with sputum MMP-9 levels. Accordingly, we suggest that vitamin D may have a beneficial role in the prevention of airway remodelling in asthma patients.